Anemia can be aroused by Chronic Kidney Disease (CKD), and it will become
severer with the increase of severity of renal Anemia. And serum creatinine is a
reflection of kidney condition, so we often wonder whether there is certain
relation between creatinine level and Renal Anemia.
Increasing of creatinine level is a sign of the decrease of hemoglobin.
In the very beginning, the primary cells in the marrow differentiates into
red blood cells, and there is a kind of glycoprotein called erythropoietin which
will take part in the process. Only with the help of factors which are able to
stimulate the formation of red blood cells, can the inactivated original
erythropoietin perform actively. As these factors are produced by
juxtaglomerular cells in the glomeruli, the secretion of these factors will be
reduced if lesions occur right in the glomeruli. Under this condition, the
damages in juxtaglomerular cells can not be avoid either. In addition, the
changes in the glomeruli will cause the decrease of Glomerular Filtration Rate
(GFR), leading to a high level of creatinine.
The level of creatinine is in positive proportion to the decrease of
erythropoietin. The higher the creatinine level is, the less erythropoietin
remained in the body. In other words, a high level of creatinine is a omen for a
high risk of Renal Anemia.
Also, the increase of serum creatinine and blood urea nitrogen, and other
toxin in blood will not only have inhibitory action to the marrow, but also
affect the metabolism of ferrum and folate, which is the necessary material for
the formation of hemoglobin. What's more, the hemoglobin in sufferers with
kidney failure are more fragile and have shorter lifespan.
Renal Anemia is a very common complication caused by Chronic Kidney Disease,
and it does have relation with serum creatinine. Proper treatment schedule needs
to include the treatment for such complications as Anemia. Also, if you want to
know more about the related information about Chronic Kidney Disease, you are
welcome to talk with the consultant online or leave a message.
