Crescent, you know how much

The crescentic is a pathology concept, is one of the basic lesions of glomerular morphology. The emergence of the crescent, often precedes the patient's renal pathological damage is relatively heavy, is an important sign of poor prognosis in IgA nephropathy. The crescent is defined as: the hemispherical structure of the Bauman sac capillary leakage of blood cells, cellulose and infiltration of mononuclear cells, the proliferation of parietal epithelial cells filling capillaries ball outside.
What is the crescent body IgA nephritis
The composition of the crescent found in a variety of causes serious damage and fracture of the glomerular capillary wall and Bowman capsule accounted for 50% of the total glomerular crescent constitute the glomerular crescent accounted for more than 50% of glomerular area, the so-called crescentic glomerulonephritis (CGN). If the kind of crescent in IgA nephropathy patients, the popular little talk, you can call: size of IgA crescent nephritis (just a strict, it is called). The crescent is often seen in many other glomerular lesions, its composition often prompt a serious condition, and poor prognosis.
The crescent not the same intervention in different diseases
Foreign scholars on the 6000 cases of renal biopsy analysis showed that: 95% of anti-glomerular basement membrane (anti-GBM), the antibody type nephritis patients crescent constitute; anti-neutrophil cytoplasmic antibody (ANCA)-related renal small glomerulonephritis, crescent about 90% of patients; immune complex type crescentic glomerulonephritis in the percentage of crescentic lesions smaller than the first two also slow disease progression. Directly related to the percentage of IgA nephropathy or prognosis of lupus nephritis and crescentic. But with similar crescent number of different diseases, the prognosis is not necessarily the same. For example, a 25% crescent composed of lupus nephritis glomerulonephritis prognosis is worse than the same crescent percentage of streptococcal infection.
Crescent poor prognosis in IgA nephropathy
Of crescentic IgA nephropathy renal pathological damage has quite a lot of negative effects, multi-segmental, cellular crescents, which common monocyte / macrophage infiltration, crescent is common in severe diffuse mesangial proliferation and (or) diffuse capillary proliferation in patients with IgA nephropathy found by renal biopsy: IgA nephropathy in five installments of the second phase there are crescent is generally believed that the more subsequent sub- period, the crescent, the greater the number, the more serious kidney damage arising as a result of crescentic IgA nephropathy with poor prognosis is an important pathological factors.
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