2012年7月12日星期四

Relevant knowledge of IgA nephropathy


Also did not carry out the age of renal biopsy for biopsy, IgA nephropathy, and glomerulonephritis are mixed up together, it is difficult to understand its true colors.
The body of an immunoglobulin A, that of IgA. Due to respiratory or gastrointestinal infection, and the other is not yet clear reasons, in vivo IgA or polymer increases, the to Erzhi onset of blood deposition in the glomerular mesangial, known as IgA nephropathy.Lesions in the glomeruli, a of nephritis.
The main manifestations of IgA nephropathy recurrence clearance episodes of hematuria, can of course also other similar nephritis proteinuria, edema, hypertension and even renal failure. Diagnosis of this disease only rely on glomerular IgA deposition, and thus must renal biopsy to confirm the diagnosis.
The so-called renal biopsy under local anesthesia, with B ultrasound imaging guidance, a tiny biopsy needle through the skin, reach kidney, "draw" some kidney tissue with a microscope (light microscopy, immunofluorescence microscopy and electron microscopy) examination, to establish whether this disease. Renal biopsy is actually quite safe, remove the kidney tissue is generally 10 glomerular glomerular terms of two million a 10 glomerular "loss" is negligible. Do not mind.
IgA nephropathy is quite common, as renal wear technology improves, to receive a kidney to wear the increase in the number of onset cases the ratio will be more.Generally speaking, the slow development of the majority of the disease, better prognosis, as long as adherence to treatment, often up to protect the kidneys, delaying disease progression and to maintain the purpose of stable renal function. Specific medication by a doctor selected under the condition of patients. For individuals, the key is 8 characters: self-protection, adherence to treatment.
IgA nephropathy are generally two types of performance, first class acute-speed recurrent gross hematuria, acute episodes of the naked eye hematuria onset of signs, but before this, often without a history of abnormal urine check. Common in children, their naked eye hematuria is more common in the upper respiratory tract infection (cold), also a small number of patients with onset of infection in the digestive tract, the time interval of more than 24-48 hours, gross hyperlipidemia sustainable for several hours or days, a small number of In addition to the naked eye hematuria, the patients there are some other similar acute nephritis performance such as a transient high blood pressure and serum creatinine increased after treatment, mitigation, but under normal circumstances.Such patients in the first naked eye hematuria attack, often marks the beginning of the disease, since patients may have varying degrees of urinary protein and (or) microscopic hematuria. The naked eye hematuria disappeared. About 60% of patients will re-emergence, repeatedly appeared in the respiratory tract infection. The second category is asymptomatic urinary abnormalities, persistent or intermittent microscopic hematuria, mild urinary protein, occasionally tube. Often found in the examination of urinary protein and (or) hematuria Prior to this, the urine protein and (or) blood in the urine how long is often difficult to ascertain. With the progress of the disease in some patients, there may be large amounts of urine protein (greater than 3.5 g per day) and severe hypertension and chronic renal failure.
In Western medicine are currently no specific treatment, but the following aspects can be.
The ① avoid the intrusion of the antigen: the naked eye the hematuria hair of recurrent infections, tonsillectomy and dental lesions

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