What are the main points of diagnosis and treatment of IgA nephropathy

So far, the disease there is no satisfactory treatment options. Of the disease associated with renal insufficiency adrenal corticosteroids with or without immunosuppressants results are not consistent. Recent data suggest that urinary protein of more than 1g / d, to impose the next day medication adrenal cortical hormone is beneficial to the improvement of urinary protein. IgA deposition of minimal change nephropathy may relieve urinary protein. Used in combination with cyclophosphamide, dipyridamole and warfarin to reduce urinary protein had no effect on glomerular filtration rate; combined use of cyclosporin A may also reduce urinary protein, and then reduce muscle liver clearance. Efficacy of phenytoin, anti-platelet drugs, the anthocyanin acid disodium diphenyl Sealand due to such drugs is uncertain. Notwithstanding the reports of urokinase may have a role to protect the glomerular filtration rate, but far from conclusive. Back and forth for tonsillitis, tonsillectomy may be useful; antibiotics in the prevention and treatment of infection may be helpful to some acute nephritic syndrome and acute renal failure for the performers. A small series of observations found that the use of fish oil preparations reduce urinary protein and increased the role of the glomerular filtration rate. Severe IgA nephropathy (glomerular filtration rate monthly decline 2 to 4ml/min), use of large doses of immune globulin intravenous infusion period, you can stop the glomerular filtration rate, improve the blood in the urine and urinary protein, but after stopping often repeated. The case of high blood pressure and severe urinary protein, glomerular filtration rate converting enzyme inhibitors can slow down the rate of decline and reduce urinary protein in severe IgA nephropathy, converting enzyme inhibitors are the preferred antihypertensive drugs. Conversion of normal blood pressure, whether effective inhibitors is unclear.
The end of advanced IgA nephropathy after renal transplantation, the transplanted kidney happen soon mesangial IgA deposition; subclinical IgA nephropathy if the donor kidney for renal mesangial IgA deposits after implantation of non-IgA nephropathy uremia often rapidly disappearing. Renal allograft associated with recurrent IgA nephropathy is not necessarily progressive renal failure in kidney transplantation, however, Shi immunosuppressive therapy including cyclosporine A also did not prevent its development. Cadaveric renal transplantation, 1 year and 3-year graft survival up to 87% and 77%, however, individual IgA antibody IgA anti-HLA antigens of renal transplant recipients, 2-year graft survival of up to 100%. reason to believe that those anti-HLA antigen antibody on the increased graft survival has played a useful role.