The two main causes of chronic kidney disease are diabetes and high blood
pressure, which are responsible for up to two-thirds of the cases. Diabetes
happens when your blood sugar is too high, causing damage to many organs in your
body, including the kidneys and heart, as well as blood vessels, nerves and
eyes. High blood pressure, or hypertension, occurs when the pressure of your
blood against the walls of your blood vessels increases. If uncontrolled, or
poorly controlled, high blood pressure can be a leading cause of heart attacks,
strokes and chronic kidney disease. Also, chronic kidney disease can cause high
blood pressure.
Other conditions that affect the kidneys are:
Glomerulonephritis, a group of diseases that cause inflammation and damage to
the kidney's filtering units. These disorders are the third most common type of
kidney disease.
Inherited diseases, such as polycystic kidney disease, which causes large
cysts to form in the kidneys and damage the surrounding tissue.
Malformations that occur as a baby develops in its mother's womb. For
example, a narrowing may occur that prevents normal outflow of urine and causes
urine to flow back up to the kidney. This causes infections and may damage the
kidneys.
Lupus and other diseases that affect the body's immune syImmunotherapy.
Obstructions caused by problems like kidney stones, tumors or an enlarged
prostate gland in men.
