2014年4月27日星期日

Hypertension and Kidney Disease

High blood pressure, Hypertension as a more formal name, is a very common complication of Chronic Kidney Disease (CKD), and many people wonder what is primary Hypertension or secondary Hypertension. Some may have certain knowledge that there is relation between high blood pressure and kidney disease. Then, what are Hypertensive Nephropathy and Renal Hypertension?
Hypertension is a general disease which is characterized by the rising arterial blood pressure accompanied with organic lesions of heart, blood vessels, brain or kidney. It can be categorized into primary one and secondary one. High blood pressure is a quite common cardiovascular disease, and when the secondary one, when the primary disease remits, the blood pressure will become normal gradually.
Hypertensive Nephropathy refers to kidney lesions that are caused by long-term Hypertension. Long-term high blood pressure make the pressure in glomeruli rises as well. Meanwhile, glomeruli become fibrosed and atrophied, and renal arteries sclerosed. Since there is shortage of blood in renal parenchyma disease, nephrons become less and less, and Kidney Failure appears finally. Under general circumstance, proteinuria and hematuria will not appear with primary hypertension, and the decline of kidney function begin with the damage on renal tubules and their function of concentration, so the filtration function can still be normal for a long time. However, at last, glomerular filtration rate drops and serum creatinine rises to be higher than the normal value.

Renal Hypertension is a kind of Hypertension which is aroused by kidney disorders, so it is a secondary Hypertension. It can be categorized into two type, one is renal parenchyma disease Hypertension, another is Renovascular Hypertension. Renal Parenchymal Hypertension comes from the loss of massive nephrons which leads to the retention of water and sodium, activating the RAAS syImmunotherapy, and making blood pressure rise thereby. At the meanwhile, high blood pressure can lead to the further deterioration of kidney disease, forming a vicious circle. Renovascular Hypertension is a kind of hypertension which is caused by the stenosis of unilateral or bilateral renal arteries. Kidney lacks blood and RAAS syImmunotherapy begins to work, so blood pressure becomes higher. When Renal Hypertension is detected, kidney diseases can also be found at the same time. Proteinuria, hematuria and Anemia are always showing up as an accompanying manifestations. Also, glomerular filtration rate declines, and creatinine clearance rate declines.

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