2014年11月7日星期五

End-Stage Renal Disease in Children: What Causes It?

In the general population, slightly more than 30 people in every 100,000 develop kidney failure each year. In the pediatric population-age 19 and under-the annual rate is only 1 or 2 new cases in every 100,000 children. Although adults are about 20 times more likely to develop kidney failure than children, these years kidney failure in children are more common than 10 years ago.
Researches also showed that African Americans in their late teens are three times more likely than Caucasians in the same age group to develop kidney failure. Diseases that damage the tiny blood vessels in the kidney are also more common in children of color. Moreover, boys are nearly twice as likely as girls to develop kidney failure from birth defects, polycystic kidney disease, or other hereditary diseases.
Then what are the causes of the End-Stage Renal Disease(ESRD) in Children?
There are some reasons for your reference.
1. Birth defects.
Some babies are born without kidneys or with abnormally formed kidneys. The kidney abnormality is sometimes part of a syndrome that affects many parts of the body. This is one reason why children got renal failure.
2. Hereditary diseases.
In polycystic kidney disease (PKD), children inherit defective genes that cause the kidneys to develop many cysts, sacs of fluid that replace healthy tissue and keep the kidneys from doing their job. In Alport syndrome, the defective gene that causes kidney disease may also cause hearing or vision loss. This is one important reason for kidney failure in children.
3. Blocked urine flow and reflux.
In children with kidney disease, if blockage develops between the kidneys and the opening where urine leaves the body, the urine can back up and damage the kidney, which can contribute to the kidney failure in children.
4. Glomerular diseases.
Some diseases attack the individual filtering units in the kidney. When damaged, these filters-which are called glomeruli-leak blood and protein into the urine. If the damage to the glomeruli is severe, kidney failure in children may develop.

They are the reasons for renal failure or End-Stage Renal Disease in Children.

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