● Glomerular High Filtration Stage
In this stage, glomerular filtration rate achieves as high as one hundred and twenty percent to one hundred and forty percent and people with Diabetic Nephropathy have enlarged kidneys. Normally, as long as patient with stage one Diabetic Nephropathy has better about their blood glucose, then the pathological changes appearing in their kidneys is reversible.
● Normal Albuminuria Stage
In this stage, the glomerular filtration rate is still high and meanwhile, intermittent microalbuminuria can be found. The excretion of protein in urine is normal at rest, but higher after exercises.
● Early Stage of Diabetic Nephropathy
In this stage, glomerular filtration rate begins to decrease and it is normal or somewhat lower than the normal value. Moreover, high blood pressure and persistent microalbuminuria are the symptoms of Diabetic Nephropathy in this stage. Furthermore, in this stage, excretion rate of protein increases, even if patients do not do any exercise.
● Clinical Diabetic Nephropathy
Usually, patients with this stage Diabetic Nephropathy will have large amount of proteinuria, swelling and high blood pressure in the following three or four years. In this stage, glomerular filtration rate is significantly lower than normal value.
● End Stage of Renal Failure
Due to the thickness of glomerular basilar membrane, glomerular capillary lumen has a progressive narrowing. More and more glomerular dies, renal function will decreases, leading to the occurrence of renal failure. Usually, in this stage, kidneys have lost almost all their functions and patients can not live a full life.
What need to be paid attention about this kind of Chronic Kidney Disease is that the natural progress of each stage of Diabetic Nephropathy is three to five years. That is to say if patients with Diabetic Nephropathy leave their disease uncontrolled, then their disease will develop into renal failure within at most twenty years. Therefore, to stop the rapid development of Diabetic Nephropathy, receiving treatment timely is very necessary.
