Generally speaking, Chronic Kidney Failure develops slowly, but the delay of treatment may finally lead to Uremia. And the pathogenesis of Chronic Kidney Failure is as following:
1. Various of pathological damages to kidney will lead to blood
microcirculation obstacles which cause ischemia and anoxia of renal tissue.
Damages to renal blood endothelial cells will lead to the infiltration of
inflammatory cells and the release of inflammatory mediators. Through this
2. The damaged renal histocyte will release a series of virulent cell factor
and growth factor which promote the transform of the healthy renal cells. These
transformed cells will continue to release toxic substances, thus aggravating
the damage on kidneys.
3. After transformed, the cells, especially the renal fibroblast will secrete
extracellular matrix which is difficult to be degraded. When large amounts of
extracellular matrix pile up in kidneys, they will replace healthy renal unites,
thus leading to glomerulosclerosis, kidney tubules & mesenchyme fibrosis and
renal vessels fibrosis.
4. With the development of renal fibrosis, functional renal unites reduces
gradually and renal function loses continuously, thus leading to the scar, and
finally, the disease will develop into Renal Failure or even Uremia.
Chronic Kidney Failure happens gradually and it usually over years. The
initial symptoms are usually very mild and could go unnoticed for years.
Symptoms usually are noticed when it is too late and little can be done to
reverse the situation.
Chronic kidney disease (CKD) slowly gets worse over time. In the early
stages, there may be no symptoms. The loss of function usually takes months or
years to occur. It may be so slow that symptoms do not occur until kidney
function is less than one-tenth of normal. The final stage of Chronic Kidney
Failure is called end-stage renal disease (ESRD). The kidneys no longer function
and the patient needs the effective treatments.