The etiological agent for this disease is hypertension leads to Renal Damage mainly through Renal Ischemia, and also damages from high TMP and high filtration inside glomerulus. With the constant development of Hypertention, Kidney arteriole construction changes, tube wall thickness increases, bad obedience, blood flow volume further decreases, endothelial cells in glomerulus capillary wall are damaged due to ischemia and anoxia. The activity to anticoagulation declines after the damage of endothelial cells, which facilitates thrombocytes’ gathering and thrombus development.
Phenotype changes after endothelial cells are activated, and release series of cell factors and tumor necrosis factors etc. which attracts inflammatory cells to penetrate the capillary and mesangium area. Glomerulus filtration barrier damages and proteins with negative charge leak out from the blood; therefore the renal fibrosis is on the onset and protein + appears in the urine in the clinical. In conclusion from the cytology, your disease is Endothelial cell disease on ischemic glomerulus irritated by Hypertension for long. Manifestations of Proteinuria and various bad feelings include Edema and nocturnal enuresis etc.
The reason for this disease is that Hypertension is not controlled well, blood pressure ups and downs or keeps a high level for long, and the glomerulus small capillary group is pressed strongly for long, which causes the ischemia and anoxia of the endothelial cells. Actually, you get a disease known as hypertensive ischemia glomerulus endothelial cells.
Well then, patients with this situation should control their blood pressure properly. Meanwhile, they should take proper treatment to repair their renal function.
