What is the cause of IgA Nephropathy?
When CKD patients with mucosa immune defect get infected in upper respiratory tract, like tonsillitis, nasitis and pharyngitis etc. and suffer from gastrointestinal tract and urinary tract bacteria infection. IgA molecule with abnormal structure in human body can combine with antibody, which can become immune complex. These immune complex can deposit on glomerulus capillary loops and membrane area with blood flowing so that mesangial cells of glomerulus capillary usually get impaired. Once these cells get damaged, they can cause hyperplasia, proliferation and activation, causing glomerulus basement membrane to lose the function of filtration. In this case, red blood cells or protein molecule are probably to leak out with urine, so the urine routine test show red blood cells or protein in the urine. Meanwhile, once mesangial cells get damaged, they can release series of inflammatory cell factors which can further aggravate the impairment of mesangial cells.
Why did you get this disease?
Just as mentioned above, IgA Nephropathy belongs to an autoimmune disease with mucosa membrane function defect. When your immunity gets decreased, bacteria and virus are more likely to invade your body. In this case, mucosa membrane on upper respiratory tract and gastrointestinal tract is probably to get infected. IgA with abnormal construction has a certain of antigenicity which stimulates human body to produce antibody. The combination of antibody and antigen can cause immune complex. These complex has a high combinative ability with binding protein and receptor in glomeruls mesangial cells. Their combination can induce hyperplasia, proliferation and activation as well as the secretion of inflammatory factors, which result in the ischemia and anoxia in kidney and trigger immune inflammatory lesion in glomerulus mesangial cells.
What is the correct way to treat this disease?
In the course of treatment, no matter what methods you take, western medicine, Chinese medicine or the combination of Chinese and western medicine, you should abide by the following principles if you hope to get proper treatment effect.
First, dilate blood vessels. Why should blood vessels be dilated? Once glomerulus capillary present immune complex deposit, various blood vessels will get impaired
and damaged which can cause bad blood circulation. And this bad circulation can cause ischemia and anoxia in microcirculation. The aim to dilate blood vessel is to promote blood circulation in various syImmunotherapys and to remit ischemia and anoxia in kidney. This process can provide a favorable condition for repairing epithelial cell and mesangial cells.
Second, Anti-inflammation. After glomerulus capillary mesangial cells get impaired, massive inflammatory factors can be released to blood circulation. That will further aggravate cells’ damage. Therefore, anti-inflammation can decrease inflammatory cells’ infiltratition and impairing to glomerulus capillary mesangial cells.
Third, Anti-coagulation, the growth of inflammatory cells in blood can increase blood viscosity, which rev up the micro-thrombosis. The application of anti-coagulation medicine is to decrease thrombosis so as to build a foundation for repairing epithelial cells.
Fourth, impaired mesangial cells can synthesize collagen I and III which cannot be degraded. These collagens bring massive extracellular matrix(ECM), inducing glomerulosclerosis. We need to take related medicines to remove these deposited ECM so that they can be discharged with urine. For the application of medicine, the scientific method is to combine Chinese medicine and western medicine, single medicine has limited effect for the treatment.
After the above four treatment, glomerulus capillary mesangial cells can get restored and its normal physical function can recover as well as its barrier function. After these function become normal, blood urine and proteinurina etc can disappear correspondingly.
Traditional western medicine is just to treat symptoms. In clinical practices, the usual treatment is to adopt hormone or immunosuppressive agent to hold proteins rather than repair kidney’s epithelial cells. The truth is protein come back again even though patients take medicines. It becomes an insurmountable challenge to decrease protein. This treatment misunderstanding lies in the wrong recognition between illness and symptom. What is our unique treatment on IgA Nephropathy, You can read consult our online expert or read another article here. Certainly, you can also send email to me to get detailed explanation.
