Mesenchymal stem cells are the best cells which boast for their differentiation
Stem Cell Therapy
Differentiation capacity Does Stem Cells Really Help Polycystic Kidney
As Mesenchymal stem cells derive from mesoblast and ecotoblast in the early
embryonic development, they have great capacity of self-renewal and
multipotency. In the certain internal environment or external environment, they
can be cultured into muscle tissue cells, cartilage cells, nerve cells,
endothelium cells etc. Therefore, mesenchymal stem cells own the potential of
developing into the necrotic renal intrinsic cells and replacing their
functions. The danger of PKD is not the disease itself but renal intrinsic cells
destroyed by it. Their replacement of necrotic cells will enormously repairs the
damaged nephrons and recovers renal functions to the greatest extent.
Supportive structure of hemopoiesis How Can You Use Stem Cell Therapy for ADPKD
Mesenchyme is embryonic connective tissue that can differentiate into
hematopoietic and connective tissue, instead of hematopoietic cells, which means
that Mesenchymal stem cells are more primitive stems than blood cord stem cells.
Through promoting hematopoietic cells embedding, Mesenchymal stem cells
transplantation enhances the production of blood, easing the local lack of blood
and oxygen in kidney. Even in treating septemia caused by infection in late
stages of PKD, Mesenchymal stem cells are able to reconstitute hematopoietic
system, if they are induced by certain external factors.
Regulating immune system Do Stem Cell Treatment Increase Kidney Function for PKD Patients
Numerous studies have proved than Mesenchymal stem cells have been applied
into treating autoimmune diseases, such as systemic lupus erythematosus and
Inflammatory Bowel Disease, in which they can secrete cytokines or promote
cellular interactions to restrain the activity of T cells, regulating immune
system. In late period, patients with PKD usually have low immunity and unstuck
internal environment. Mesenchymal stem cells tend to regulate or restore immune
system to improve medical conditions of the patients.
Stem Cell Therapy for Kidney Failure Because of PKD
In treating Polycystic Kidney Disease, the main function of Mesenchymal stem
cells is to repair and create new renal intrinsic cells, while that of cord
blood stem cells is to promote the production of blood, easing local shortage of
blood and oxygen in kidneys.