Urea Acid is the final product of purine metabolism. Dysfunction of purine
metabolism leads to the excessive secretion of urea acid. In addition, the
decline of renal function will give rise to lower excretion of urea acid. These
two above reasons can result in increase of urea acid content in blood, and then
these urea acid accumulate in the blood and cause Hyperuricemia.
High urea acid content in blood easily leads to deposition of urate in
joints, which is commonly called Gout. And when there is more and more
deposition of urate in renal glomerulus and renal tubules, damages to the kidney
will be caused or aggravated.
The two main causations of Hyperuricemia, namely, are more secretion of urea
acid and less excretion of urea acid. Referring to the former causation, we can
peruse a diet change to food low in purine. And according to data, people who
take too much sea foods are more vulnerable to this disease. So, patients with
this Hyperuricemia or kidney problems should pay much more attention to intake
of sea food.
However, starvation causes the body to metabolize its own (purine-rich)
tissues for energy. Thus, like a high purine diet, starvation increases the
amount of purine converted to uric acid. Starvation also impairs the ability of
the kidney to excrete uric acid, due to competition for transport between uric
acid and ketenes.
In case that the excretion of urea acid is stocked, medicine should be
adopted immediately to enhance the degradation of deposited urate. Xanthine
oxidase inhibitors decrease the production of uric acid, by interfering with
Xanthine oxidase Uricosurics increase the excretion of uric acid, by reducing
the reabsorption of uric acid once the kidneys have filtered it out of the
blood.
In addition to Gout, high content of urea acid can also give rise to vascular
diseases like hypertension, arteriosclerosis and so on. So the taking under
control of blood pressure is of great important.