The first stage of Diabetic Nephropathy is called ultrafiltration, which means the filtration is much. The size of the kidney also increases in this stage due to hard working. The purpose is to discharge the sugar out. The load from kidney is heavy, kidney becomes bigger. What we should point out is that there is no symptom in the first stage.
The second stage of Diabetic Nephropathy is called clinical stage. In this stage, patients can also not be diagnosed with Diabetic Nephropathy easily. Some have a little high blood pressure and the high blood pressure is not steady. At this moment, if patients take a renal biopsy or puncture, they can find out that in kidney, there is damage or lesion. However, urinalysis can not tell the change and there are also no clinical manifestations in clinic.
In the third stage of Diabetic Nephropathy, there starts to appear some steady manifestations such as high blood pressure. There is also protein in the urine. The third stage is a critical stage for patients with Diabetic Nephropathy. After treatment, the disease can be reversible as long as patients with Diabetic Nephropathy take effective treatment. In the fourth and fifth stage, patients’ Diabetic Nephropathy is difficult to get recover with the damage become more and more.
So it is quiet necessary for patients or normal people to have examinations on urine. microalbumin is an important index which can identify whether people have tend to develop into kidney disease.
In the fourth stage of Diabetic Nephropathy, patients will have a large amount of protein in urine. No matter what measures they take, protein in urine is hard to diminish. Blood pressure increases continuously. Blood urea nitrogen and serum creatinine increase as well.(High Creatinine Level)
In the last stage, patients with Diabetic Nephropathy develop into renal insufficiency stage. Many symptoms come out such as high blood pressure, edema, increased urine or no urine, pain in the back, and so on. In addition, patients with Diabetic Nephropathy may also have other symptoms such as anemia, fatigue, osteoporosis and so on.
