Polycystic Kidney Disease (PKD), also called Potter syndrome or Perlman syndrome,
The Autosomal Dominant Polycystic Kidney Disease is caused by two genes:
ADPKD1 and ADPKD2. ADPKD1 lies in the short arm of chromosome 16, while ADPKD2
is located on the short arm of chromosome 4. As is reported, patients with
ADPKD2, especially the female patients, tend to have less severe ill conditions
than patients with ADPKD1. The signs or symptoms of ADPKD1 like kidney function
declining or renal failure may appear later than that of people with ADPKD2.
ADPKD2 is responsible for 90% cases of Autosomal Dominant Polycystic Kidney
Disease. With autosomal dominant inheritance, there is a 50% chance that the
disease will pass to the children of one patient with PKD.
The general course How to shrink Kidney Cyst(Renal Cyst)
How to Shrink the Cyst With Polycystic Kidney Disease(PKD)
Patients are born with cysts which are too small to check out. At their
twenties, cysts usually have began to grow but without any visible or
perceptible symptoms. When patients reach their thirties or forties, cysts in
their kidneys will get bigger shapely. Blood pressure becomes slightly high
among those patients, which can further speed up the deterioration of PKD. After
about ten years of high blood pressure, namely at their forties, patients will
have the tumid cysts and severe symptoms occur such as hemature, proteinuria and
flank pain. The renal function begins to fail. After the age of fifties, PKD
will cause real insufficiency or renal failure as well as cysts in liver and
other organs. The severe complications will also occur such as cerebral aneurysm
and heart diseases, which take the main responsibility for the death of patients
If PKD is on exertion, flank pain and high blood pressure are its first
symptoms. Flank pain is persistent or paroxysmal, which will become severe after
tiredness. With high blood pressure, patients may have headache and dizziness.
Patients can feel the cysts when they touch their back or waist. About half of
patients with PKD will have hematuria and one fourth of the patients show renal
colic, frequent urination and urgent urination. In late stages of PKD, renal
insufficiency or Kidney Failure comes up with their severe symptoms.
Although the pathological course of Polycystic Kidney Disease is still
unknown, the damaged renal intrinsic cells and its clinical symptoms can be
assured. Therefore, there can be a way of treating PKD Polycystic Kidney Disease