2014年11月3日星期一

What Circumstances Can be Pregnant for Patients with CKD

The morbidity of Chronic Kidney Disease has reached to 10%. It is becoming a serious public health issue day by day. A great number of patients are women in reproductive age. Whether can these patients with Chronic Kidney Disease have a pregnancy? How can they give birth to a healthy baby, having a happy and perfect family?
First of all, we should know the relationship between pregnancy and the kidney. Pregnancy will increase the burden of the kidney leading to work overload. For pregnant women, their serum creatinine level(High Creatinine Level) is lower than common people. In general, people argue that more than 70μmol / L is highly indicating the decline of renal functions. Many gynecological diseases have an adverse effect on kidney, such as pregnancy-induced hypertension, placental abruption and disseminated intravascular coagulation that can lead to serious kidney damage and even Acute Renal Failure. On the other hand, pregnancy may aggravate the progress of existing kidney disease. Whether it is Chronic Nephritis, Rheumatism Kidney Damage, Polycystic Kidney Disease, Kidney Stone or hereditary kidney disease can cause rapid deterioration of renal functions. And this also leads to significant increase of pregnancy complications that threatens the safety of pregnant women and the fetus.
According to the literature, for the fetus of patients with Chronic Kidney Disease, the incidence of neonatal prematurity, fetal distress, fetal death, growth retardation and neonatal asphyxia is significantly higher than common people's. So is the maternal complication. Is it impossible for patients with Chronic Kidney Disease to have a baby as ordinary people? Certainly not, in certain circumstances, patients with Chronic Kidney Disease can still be pregnant and give a birth.
The conditions as follows:
1. Normal blood pressure.
2. Normal renal functions.
3. Do not have a mass of proteinuria(Proteinuria and Kidney Disease) especially in the scope of Nephrotic Syndrome.
4. Pathological type of kidney is light without obvious tubule interstitial and vascular lesions.
Even if the patients own the conditions above, the pregnant women also need to strengthen the monitoring during pregnancy. In the early stage of pregnancy, they should take quantitative test for urine protein, kidney functions, blood pressure and the growth of fetus every two weeks. After the early stage of pregnancy, they should take the examination once a week. Once it appears that the renal functions fall down sharply, blood pressure goes up out of control and a large amount of proteinuria do not reduce but increase and so on. Make a decision decisively balancing the pros and cons and giving up pregnancy in time if necessary. Under controllable conditions, once the fetus becomes mature, during which close monitoring should be make, the pregnancy must be ended up immediately.

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