A richblood supply is needed constantly by the kidney to continuously bathe it with vital renewed nourishment. Anything which decreases renal blood flow, will rapidly accelerate the downward progression of kidney disease.
Additionally, the release of renin is triggered by constricted kidney blood flow. This outpouring of renin quickly raises blood pressure, sometimes causing spikes in blood pressure with wide variations. In turn, high blood pressure can also worsen the PKD(Is High Blood Pressure a Sign of PKD (Polycystic Kidney Disease)).
High blood pressure makes the heart work harder and, over time, can damage blood vessels throughout the body. If the blood vessels in the kidneys are damaged, they may stop removing wastes and extra fluid from the body. The extra fluid in the blood vessels may then raise blood pressure even more. It's a dangerous cycle.
In addition, high blood pressure is one of the leading causes of kidney failure of PKD(How Many Years Will PKD Develop into Kidney Failure). People with kidney failure must either receive a kidney transplant or have regular blood-cleansing treatments called dialysis.
From the above, we can find a series of damage caused by smoking for PKD patients.
