Although kidney at the beginning has increased filtrating rate for a while, the presence of glucose increases the amount of filtrates passing through the functional units of the kidneys, which lead to more protein being filtered across the glomerular membranes. This is followed by the appearance of small amounts of protein in the urine. In turn, the protein which filtered out of body damages the membranes leading to increasing losses of protein in the urine and more damage to the kidneys.
On the other hand, the increased tendency to atherosclerosis in diabetes also lead to damage in kidney. There is an increased level of blood fats with deposits in the walls of the blood vessels. Where this affects the blood supply to the kidneys, the diminished blood flow can also damage the kidneys.
The above mentioned tells us when diabetes develops into diabetic kidney disease or how diabetes affect kidney.
