The incidence, reported from all over the world, quite differs from each other, while the most frequent area is likely to be the Western Pacific Region. Of the proved patients with glomerular disease by biopsy, Japan is reported to take up 50%, the Europe about 10% to 30%, yet America less than 2%. And the reports from china vary in different areas, approximately accounting for 20% to 30%. The result is obviously impacted by the native renal biopsy indications and urine census, e.g. it is more or less than 5% in Britain. Nevertheless, this data in a group of asymptomatic hematuria biopsy from Scotland goes up to 37%. The disease is more common in men and male to female ratio is about 2:1. There are also differences between races. For example, the Indians in New Mexico take up 35%, while it is very rare in the black. Although it is founded out that the IgA2m(1)in the black is obviously low than that in the white, it has not been confirmed that it is definitely connected with the low incidence.
Since 1998, it is indicated in some reports that the disease tend to be a familial one, and at least that there exits genetic predisposition in some patients with chronic IgA nephropathy. HLA is analyzed to be connected with BW35 and DR4. A recent group of analysis about ESRF caused by IgA point out that B 27 and DR1 are on the increase while DR 2 is on the decline.
[Clinical Manifestation] How to Reverse Chronic Glomerulonephritis Is There a Natural Cure for Glomerulonephritis Do You Recommend Astragalus for Chronic Nephritis Patients Can Homeopathic Treatment Cure Glomerulonephritis
For typical cases, it usually takes the patients several hours to two days to have gross hematuria after infected in the upper respiratory tract. The symptom lasts for several hours to several days, some even up to 1 week. The total number of such patients accounts for about 40% to 50%, slightly higher in children. Some individuals may suffer from severe backache and stomachache, which may be related to intestinal IgA vasculitis. The other common manifestation of this disease is asymptomatic hematuria and/or proteinuria, accounting for 30 % to 40%. 20% to 25% of the above–mentioned may encounter gross hematuria one or more times during the process.Home Remedies for Chronic Glomerulonephritis Both Kidneys Are Shrunk with Glomerulonephritis How Long to Cure Glomerulonephritis
Nephrotic syndrome can be found in 5% to 20% of patients, most of whom are children and youngsters. It is a type of diffuse proliferative disease with or without glomerulosclerosis. In addition, at times the phenomenon that mainly refers to Mesangial IgA deposition can also appear in the minimal change nephropathy, which is characterized by foot process fusion. Some less than 10% of the patients represent acute renal failure, and all of them can relieve themselves, 20% to 25% of whom are required to be dialyzed due to the (crescentic glomerulonephritis) CGN. In the procedure, patients that are subjected to nitrogenous matter retention take up about 25%, and that with high blood pressure at the onset about 10%, which significantly increases in patients over 30 years old; along with prolonged process, patients associated with high blood pressure exceed 4
[Prognosis]
The disease may have spontaneous remission, which takes up about 4% to 20%. Each year, about 1% to 2% of the patients get caught into the end stage of renal failure. Statistic analysis from life table shows that 80% to 90% of the patients can survive for 10 years, and about 35% of the patients are estimated to develop into uremia while others suffer persistent hematuresis or proteinuria. The elements which caused the poor prognosis are as follows: onset with renal insufficiency, proteinuria exceeding 1.5g/d, high blood pressure and no gross hematuria; symptoms can be detected with renal biopsy, such as glomeralosclerosis, interstitial fibrosis, invasion of glomerular capillary, diffuse hyperplasia and crescent formation, etc.
