One of the most important functions of kidney is to excrete waste products in the blood. And the sound working of glomerular filtration guarantees the expelling of harmful substances and wastes. So the filtration ability of glomerulus can never be given too much attention to.
In order to fully investigate what lead to the decrease of glomerular filtration rate, we need to firstly make clear the functional principles of glomerular filtration .
Researches have shown that, it is the mechanical barriers and the charge barriers of glomerulus working together that consists of the filtration .Herbal Medicine Treats Kidney Disease Herbal Medicine and Kidney Disease Hot Compress Therapy for Kidney Disease Micro-Chinese Medicine Osmotherapy
Mechanical barriers refer to that glomerulus can let go of small molecular substance and prevent the pass of micro-molecular substances. As most of the toxic substances in blood are small molecules, they can be selectively excreted into urine. Some useful substances are small molecules, such as some kind of protein, then how to prevent the filtration of protein? Here comes the charge barrier of glomerulus. Glomerulus can permit the pass of substances with positive charge and obstruct those with negative ones. This function of glomerulus can prevent the leakage of useful small molecular substances like protein. In addition, some useful small molecules with positive charges can be reabsorbed by glomerular tubules. By this, the excretion of wastes and other harmful substances, as well as the retaining of useful substances can be guaranteed.
Further studies on glomerular filtration show that there are mainly four types of cells play important roles in this process.Chinese Herbs for PKD Micro-Chinese Medicine Osmotherapy for Polycystic Kidney Disease Acupuncture for Kidney Disease Medicated Bath and Kidney Disease Stem Cell Therapy Treats Kidney Disease or Kidney Failure
Glomerular blood capillary endothelial cells together with Mesangial cells consist of the mechanical barrier, and the epithelial cells of glomerular blood capillary form the charge barrier. In addition, epithelial cells of glomerular tubules have the ability of reabsorbing useful substance with positive charges.
So, if there is a normality of glomerular filtration rate, something must be wrong with one or some of these cells.
