2015年11月5日星期四

Causes of Anemia in Polycystic Kidney Disease

Few people know Polycystic Kidney Disease (PKD) starts in kidney tubules andStage IV PKD, Creatinine 3.8, Hematuria and Proteinuria
fewer people why patients with PKD may have anemia which mainly results from the damages on the epithelial cells of the glomeruli. From the point of Chinese medical science, organs and systems, in which there are complex relations, compose of one whole body and the lesion in one organ or system will affect other organs and systems. Renal anemia in Polycystic Kidney Disease (PKD) is mainly attributed to hematuria and the decreasing secretion of erythropoietin.
Hematuria Treatment for End Stage PKD, Anemia and Hematuria
About twenty-five percent amount of blood will pass though kidneys and be filtrated by nephrons in kidneys. With the growth of cysts, the normal nephrons can be squeezed to be deformed. The renal intrinsic cells will be destroyed in nephrons, losing their functions. Especially, the damage on the epithelial cells of the glomeruli will result in hematuria. The epithelial cells have orifices and carry negative charges, which can prevent blood cells fleeing. Squeezing other renal tissues, the growth of cysts tends to cause local lack of blood and oxygen in kidney, which stimulates epithelial cells to proliferate and swelling. The proliferating and swelling will make the size of orifices bigger and weaken the power of negative charge on epithelial cells, which cause blood cells to release into urine. Hematuria is usually microscopic hematuria among patients with Polycystic Kidney Disease (PKD) .
Decreasing secretion of erythropoietin How to Treat Polycystic Kidney Disease 3cm with Hematuria
Although the generation of Erythropoietin is unknown, we can assure it is produced in kidneys. What’s more, erythropoietin stimulates marrow to secrete red blood cells. Most of scholars agree that erythropoietin plays an important role in promoting erythropoietin responsive cells from marrow to differentiate into proerythroblast. In addition, it may have the functions of maturing those proerythroblast and lead red blood cells into peripheral blood vessels. Numerous studies show that the lack of oxygen will decrease the amount of secreted erythropoietin. It is through suppress renal tissues that Polycystic Kidney Disease (PKD) arouses the lack of blood and oxygen in kidney and further causes anemia.Hematuria in Polycystic Kidney Disease

Therefore, the medicines to replenish erythropoietin are popular among patients with Polycystic Kidney Disease (PKD) . However, in order to really ease anemia, the key point lies in shrinking cysts and repair the damaged kidneys.

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