The patient is now 46 years old and has two sons who are eleven and thirteen years old separately. Seven years ago, he had a blood test and indexes show a higher serumcreatinine level and he was diagnosed as Chronic Kidney Disease. Two years later, protein urine occurred to both of his two sons. The patient’s wife is healthy and has no kidney disease history. However, one of his brothers has only one kidney working, and the patient’s uncle died of renal failure, and the patient’s father died of pancreatic cancer.
Symptoms occur to the patients include edema in the eyelids and lower limbs, frequent fatigue, back pain and especially at night, but there is no high blood pressure. Kidney biopsy was conducted a year ago, and indexes show that there was not Fabry Disease and could not make sure whether it was hereditary or not.
His two sons have similar symptoms as him like eye bottom color changes into red and then to obvious black, and there are black spot when they are looking at things. Eye examinations on the patient’s older son show that there exist eye form changes. And these two boys always complain of discomfort with eyes.
Nephritic symptoms on his two sons were detected four year ago. And the patient and his two sons all suffer from hearing problems. For example, when the TV sound is turned to the maximum loud they will all lose their hearing ability, and this situation never occur to his wife. In addition, since six years ago, he has been expiring ear pain and tinnitus, and ear examination has proven no problem with the ears.
Other Kidney Disease symptoms include ice-cold feelings in both hands and feet, occasional athralgia and light pink color of nails.
The correspondence from doctors of the hospital
How are you?
Genetic Glomerular Disease is the Diseases of the Renal Glomerulus, which not only possess with genetic genes, but also has its own hereditary feature by Genetic Testing. However, as the difficulty in diagnosis, there is a limitation to classify according to clinic, tectology, morbid physiology, and genetic features.
ALPORT syndrome is a hereditary disease, with the frequent recurrence of hematuresis, nerve deafness and progressive chronic renal failure being the main clinical symptoms. And some patients may have eye disease at the same time.
Pathology: astigmatoscopy may show no glomerular change in the early stages, but with the worsening of illness condition, pathological changes may occur to many glomeruli.
Nail-patellar syndrome: clinical manifestations include dysontogenesis of nails and patella, abnormality of eye, as well as symptom of kidney damages. .
Pathology: astigmatoscopy shows that there is a lighten part made of collagenous fiber in the irregular incrassated glomerular basement membrane, and these parts take the shape of ‘bug bit’ sample.
According to the description of your disease history, we consider the above two kinds of genetic kidney diseases are possible for your case. For, these two kinds of disease are similar, so are the morbidities. It is very difficult to make identify. The diagnosis should be combined with the clinical manifestations, but metaphysics. Through the analysis of DNA, pathological biopsy, and immunological test, the disease can be identified clearly. You should recheck to explicit.
About the treatment of genetic kidney disease, the diagnosis is actually important. However, whatever the causes of kidney disease, the kidney damage has been confirmed. What’s more, there is a DNA test during your reports, which does not mention that the Alport syndrome has been excluded clearly. We suggest you to take another COL5A5 for better treatment, but this is not the most important. No matter how clearly will the disease and causation be identified, you still have to find out an effective method to recover your damaged kidney..
And , the effective method is to use Micro-Chinese Medicine Omsotherapy and Immunotherapy therapy to repair the renal lesion directly, so at to improve the kidneys gradually.
So, at present, we suggest you to take treatment immediately, so avoid the disease deterioration.
If you are interested in our therapies, I would like to introduce that for you in the further emails.
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