Diabetic Nephropathy is one of serious complications of Diabetes, and it is
one main cause of end stage of Chronic Kidney Disease(CKD). Diabetic Nephropathy
is the main micro-blood vessel complication of Diabetes. Diabetic Nephropathy
mainly refers to Glomerular Sclerosis, one Glomerular Lesion caused by the
damage of blood vessels. There are no symptoms in the early stage.
Main Reasons of Diabetic Nephropathy
Diabetic Nephropathy occurs among patients with diabetes over ten years.
Proteinuria is the obvious early symptom of Diabetic Nephropathy. According to
clinical practices of dozens of years, the main reasons of Diabetic Nephropathy
are as following:
1. High Blood Sugar
Poor control of blood sugar speed up the process of Diabetic Nephropathy. The
increase of blood sugar and glycosylation wastes arouses proliferation of
mesangial cells, more extracellular matrix, expansion of mesangial membrane,
incrassation of basilar membrane.
2. Abnormal blood flowing condition of kidneys
a) IV Collagen of glomeruli makes basilar membrane thicker leading to
diffusive and segmental mesangial lesion. As a result, it causes Glomerular
Sclerosis.
b) When there are too much blood sugar, high perfusion, high filtration and
crossing high pressure of blood capillary enlarge the mesangial cells and arouse
the foot fusion of epithelial cells, leading to the drop of epithelial cells
from basilar membrane.
c) Due to high blood pressure, more proteins leak out of blood and accumulate
in mesangial area and renal basilar membrane, leading to matrix proliferation
and diffusive Glomerular Sclerosis.
3. Hypertension(High Blood Pressure and Kidney Disease)
Hypertension is not relevant with Diabetic Nephropathy directly. But primary
Hypertension and high blood pressure during the treatment can speed up the
worsening process of Diabetic Nephropathy, so as to more protein leaking out of
blood.
4. Inherited Factors
Most patients with Diabetes don’t suffer from Chronic Kidney Disease, but
some patients who control blood sugar well stand Diabetic Nephropathy. Besides
that, the incidence of Diabetic Nephropathy shows the familial aggregation.
Meanwhile, the incidence in different races are various. All these show that the
occurrence of Diabetic Nephropathy is related to inherited factors.
Due to insufficiency of Diabetes absolutely or relatively caused by different
reasons, the metabolism of sugar, protein and fat is obstructed, leading to the
main symptom of Chronic Blood Sugar. Diabetes can cause damage to the whole
kidneys. Patients with Diabetic Nephropathy find continuous Proteinuria, they
should take timely proper treatment to avoid the end stage of Chronic Kidney
Disease—Uremia.