Proteinuria is one common clinical manifestation and early symptom of kidney
disease. Proteinuria refers that protein content in daily urine is more than
150mg. for patients with kidney disease, amounts of protein in urine can cause
series of clinical symptoms. It is also a important factor influencing prognosis
of kidney disease. so patients should take great notice of Proteinuria.
Therefore, we should touch with beginning of causes of Proteinuria.
Normally glomerular filtrating membrane can prevent most of plasma protein
from leaking out of blood, and only a few proteins enters into glomerular
filtrate. When kidneys are damaged, the filtrating function of glomeruli
strengthens and makes many proteins leak into glomerular filtrate. The amount of
proteins outdistances that of reabsorption of renal tubules, so these proteins
go into terminal urine forming Proteinuria. This condition occurs among primary
or secondary glomerular diseases, renal circulatory disturbance, anoxia and so
on. Urine protein is 2g-10g/24hs, mainly albumin.Stem Cell Therapy Treats Kidney Disease
Besides that, another possible condition is due to broken reabsorption
function of renal tubules. The amount of absorbed proteins decreases so as to
Proteinuria. This reason often appears glomeruli-interstitium diseases like
pyelonephritis, analgesic nephropathy, antibiotic kidney lesion, heavy metal
poisoning, inherented polycystic kidney disease and various inherented tubule
diseases. The amount of urine protein is less than 2g/24hs commonly, often about
1g/24hs. This kind of urine protein is mainly small molecule protein, rarely
albumin.
Proteinuria, the most common manifestation of chronic nephritis, is regarded
as the result of kidney disease. In fact, the abnormal urine protein and its
quantity are not only a detection of lesion, but also a independent factor in
the disease process. According to recent studies of Shijiazhuang Kidney Disease
Hospital, all Proteinuria condition is closely relevant to the process of chronic
renal failure, and any interference of decreasing urine protein is beneficial to
slow the process of kidney disease.
The damage to kidneys Proteinuria brings about shows these following
aspects:
First, urine protein is toxic to mesangical cells of glomeruli. In the stage
of renal failure, a large number of plasma protein accumulate in mesangial area.
These accumulated substances can induce lesion and proliferation of mesangial
cells, and increasing mesangial matrix, leading to glomerulosclerosis.
Second, urine protein can damage tubule-interstitium. In normal condition,
the small amount of protein filtrated by glomeruli is absorbed by epithelial
cells of renal tubules and are degraded by lysosomes. In pathological condition,
the strengthening permeanability of glomeruli makes amounts of plasma proteins
leak into renal tubules. the excessive albumins stimulates lysosome activity,
leading to cell damages.
Third, amounts of urine protein promote increasing ammonia which can cause
processive interstitium lesion. In addition, reabsorption and degrading of these
protein need more extra energy and make amoxia of tubule cells.
The treatment of proteinuria.Treatment for Kidney Disease Patients With Weight Gain and Proteinuria
Once Proteinuria appears, it is vital to control Proteinuria actively and
timely. So how to treat Proteinuria? The pathological reasons of Proteinuria are
the damage of glomerular filtrating function and reabsorption ability of renal
tubules. the common western treatment applies hormones or immunosuppressive
agent such as prednisone and cyclophosphamide, which relieve clinical symptoms
like Proteinuria. But there are many side-effects at the same time like
leukocytopenia, kidney lesion and so on. Therefore, Shijiazhuang Kidney Disease Hospital(Huaxia Nephropathy Research Institute) doesn’t propose using western hormones and immunosuppressive agent but
apply Michronized chinese medicines to treat Proteinuria. The micronized chinese
medicines have eliminating function. The active substances of chinese medicines
can strengthen phagocytic activity of phagocyte and limit excessive immune
reactions. The accumulated immune complex and other macromolecular substances
are easy to be degraded and then are removed out of body along with terminal
urine. The clinical manifestation change is that the terminal urine becomes
cloudy. That is because of removed immune complex and other proteins. In that
condition, the detection of urine protein is negative.Advisable Foods for Glomerulonephritis Patients with Proteinuria and Other Options Than Medicines to Reduce Proteinuria in Diabetics
Since that patients learn about Proteinuria and the treatment, they know how
to deal with this symptom when this condition occurs. Only when patients choose
standard treatment timely and effectively, they can control disease process and
avoid end stage-Uremia. As for Proteinuria, if you have any other problems, you
can also consult our online experts or send e-mail to me. we will try our best
to help you.