The clinical manifestations of Uremia are complicated, which can mention any 
organs and tissues of the whole body.
1. Symptoms in gastrointestinal tract
The symptoms in gastrointestinal tract are the earliest and the most common 
ones. At the beginning, there are asitia, uncomfortable feeling in belly and so 
on. And then some symptoms like nausea, vomiting, diarrhea, uric smell in mouth, 
ulcer of mouth mucosa and so on.
2. Symptoms in nerve 
Drooping spirit, fatigue, dizziness, headache, poor remembrance, insomnia and 
so on. Some patients also suffer from limb numbness, burning pain in hands and 
feet, skin itch and so on. In the late stage, some severe symptoms appear like 
drowsiness, dysphoria, delirious speech, muscle twitch, v, coma convulsions, and 
so on.
3. Symptoms in hemopoietic 
Anemia is unavoidable symptom of patients with Uremia. Besides that, there 
are ecchymosis, epistaxis, bleeding gums, melena and so on.
4. Symptoms in respiratory 
Deep and long breath during acid poisoning.
5. Manifestations of skin.Severe Fatigue With Stage 4 Kidney Failure
Skin tarnishes, and is dry and desquamative. In severe condition, Uremic 
Frost may appear, and it can stimulate dermitis caused by Uremia. Patients feel 
very itching.
6. Metabolic acid poisoning.Does Kidney Bacteria Cause Skin Itching Disease
Patients with Uremia suffer from various severity of metabolic acid 
poisoning. They will bear fatigue, disesthesia, deep and long breath and even in 
comatose state.
7. Dehydration or edema Can Pulmonary Edema Cause Low Grade Fever in ESRD
One side, due to breakdown of renal functions, patients have to bear these 
symptoms like diuresis, enuresis nocturna, asitia, nausea, vomiting, and 
diarrhea. These all can cause dehydration. The other side, because of poor 
ability of water expelling, if patients take in much water, patients will suffer 
from edema.
8. Electrolyte disorder
Low sodium Is There a Medicine for End Stage Renal Disease (ESRD)
One side, patients with poor ability of regulating sodium are easy to stand 
hyponatremia. The common manifestations include fatigue, asitia, apathetic 
facial expressions, in addition to severe ones like nausea, vomiting, lower 
blood pressure. The other side, if patients take in too much sodium, retention 
of sodium and water will appear and causes edema, hypertension, and even heart 
failure.Stem Cell Therapy Treats Kidney Disease
Hypocalcemia and hyperphosphatemia
Due to poor renal functions , patients can't remove phosphoruria, making 
phosphorus of blood increase. The combination of phosphorus and sodium prevents 
the absorption of calcium, leading to hypocalcemia. Hyperphospheremia and 
hypocalcemia induce hyperparathyroidism arousing obstacles of bone 
calcification. In that condition, patients suffer from bone diseases caused by 
Uremia, such as fibrillated ostitis, osteomalacosis, osteoporosis, bone 
sclerosis and so on.
Hypokalemia or hyperkalemia
Patients, who bear asitia, diahrrea and take lots of diuretic, may suffer 
from severe hypokalemia. The manifestations include: general fatigue, softy, 
numbness, arrhythmia, and even drowsiness or coma.
When patients take too much potassium-sparing diuretics and input more stored 
blood, who bear infection, acid poisoning, as well as with anuria in the end 
stage, they will suffer from serious hyperkalemia. The manifestations are: 
arrhythmia of different degree, heart arrest and so on.
Hypermagnesemia
Hypermagnesemia is rarely seen. But when patients take magnesia agent or 
suffer from serious infection or acid poisoning, magnesium of blood may increase 
with the following manifestations: accidi, drowsiness, muscle inability, nausea, 
vomiting, disoder of defecation, and arrhythmia, and so on.
