Recently, an investigation for 1200 patients with acute renal failure show
that 28.9% of them iare caused by taking nephrotoxic medicines. That is to say,
they have to depend on dialysis for survival in their rest life just because of
careless medicine intake.
Then we are curious that what medicine can damage kidney and how to avoid
these injuries.
Kidney is the most important secretion organs, most of medicines can be
discharged through urination. Through renal compression, the content of
water-soluble medicine in urine can reach up to 100 times that in plasma. If
this medicine are nephrotoxic, it can be imaged what damage they can incur to
kidney.
1. Antibiotics.Stem Cell Therapy for CKD Stage 5 Patients
Above all, Aminoglycosides can arouse tubular necrosis. Their nephrotoxic
strength can be ranged as Neomycin, Gentamycin, Kanamycin and Amikacin,
tobramycin and streptomycin, their nephrotoxin are decreasing one by one. In
clinical practices, gentamycin are the most commonnephrotoxic medicine. The
longer medicine be taken, the more severe toxin can cause.
The second type is Penicillin and cephalosporin.Micro-Chinese Medicine Osmotherapy and Stem Cell Therapy
Penicillin can cause various allergic mesenchyma nephrotitis, and methicilin
and ampicillin are very common in clinical practices. Large dosage of Penicillin
G, etc can impinge tubular on reabsorbing potassium, which can cause
hypokalemia. The first generation of cephalosporin can cause nephrotoxic
impairment, especially for cephaloridine. Whereas, cefalexin and Cefradine has
unobvious nephrotoxic damage on kidney. Cefazolin, the third generation
cephalosporin like cefotaxime, cefoperazone also has a slight nephrotoxic injury
to kidney. Renal impairment caused by penicillin and Cephems antibiotics are
usually irreversible. Most patients can recover if they stop taking these
medicines.Stem Cell Therapy Treats Kidney Disease
The third one is tetracycline. This medicine can not cause nephrotoxic damage
to kidney, it can increase the concentration of blood urea nitrogen which can
aggravate the illness condition of patients with kidney disease. Otherwise, the
metabolic product of overdue or deteriorated tetracycline can cause a direct
impairment to kidney. Demeclocycline can trigger renal insipidus and acute renal
failufe. Doxycycline can not arouse azotemia generally.
The forth one is anphotericin. This medicine can result in azotemia, tubular
necrosis. The strength of nephrotoxicity is associated with dosage
administrated. Old people and people who have insufficient blood volume are more
likely to encounter renal impairment.Shijiazhuang Kidney Disease Hospital and Huaxia Nephropathy Research Institute
The sixth one is rifampicin. People who are allergic to rifampicin are more
likely to suffer from acute Mesenchyme Nephritis which usually happens when
people take medicines discontinuously. Some patients are even adjoint with liver
injury, plate decrease and hemolysis in blood vessels.
The sixth one is sulfanilamide. This medicine can cause obstructive
nephropathy, allergic vasculitis, messenchyme nephritis and nephritic
syndrome
Cold medication and analgesic-antipyretic
There are variety of cold medication in market. The prevalent types in
clinicalpractices are mainly analgesic-antipyretic and anti-allergic
medications. If taking two or more cold medication simultaneously, people are
more likely to suffer from renal lesion induced by medicines. In clinical cases,
analgesic-antipyretic can cause many kinds of renal lesion, the earlier symptoms
include renal concentration function decline, frequent urination and enuresis
nocturna. Some patients can not present any symptoms but present renal failure
over time.
Hypotensor.Is There any Treatment Available for Kidney Problem and Is There a Natural Remedy for CKD
angiotensin converting enzyme inhibitor (ACEI) is a prevalent medicine in
clinical practices due to its pleasant function on decreasing blood pressure. In
addition, it can reduce proteinuria(Proteinuria and Kidney Disease). However, it is reported that the first
generation of ACEI can induce acute reversible renal failure, acute messenchyme
nephritis, renal failure aggravation and hyperkalemia etc. Though the
newly-developed ACEI cause less side-effects obviously, it is advisable for Chronic Kidney Disease(CKD) patients whose Serum Creatinine has exceeded 265 umol/L not to take this kind of
hypotensors, preventing renal function aggravating and hyperkalemia.
Hypoglycemics.Treatment Options for Stage 4 Chronic Kidney Disease (CKD)
Melbine DMBG can be digested without liver metabolism, they get secreted with
original form through kidney. Under normal dosages, this medicine can not impair
Dietetic patients with normal renal function. However, DMBG and lactic acid are
more likely to accumulate in human body if renal function encounters problem and
this can cause acid poisoning. Hence, it is advisable to monitor renal function
regularly if patients take medicine for long. Patients need to stop taking DMBG
once Serum Creatinine exceeds 133umol/L.Is Stage 4 CKD (Chronic Kidney Disease) Curable
Undoubtedly, there are still some medicines which are still obscure about
their nephrotoxicity. But one point is clear that Chronic Kidney Disease(CKD) patients need to pay more
attention to this when you need to take some medicine to treat other diseases,
like controlling blood pressure, treating cold or infection etc. Because the
majority of metabolic product of these medications are discharged by kidney,
once renal function encounters dysfunction, kidneys’ filtration and
concentration can not perform well. In this case, these nephrotoxic medicines
will accumulate in CKD patients’ body and induce further damages to those
remaining nephrons. At last, patients with Chronic Kidney Disease progress
rapidly into acute renal failure and Uremia.