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Cautious to Nephrotoxic Medicines in Kidney Failure

Recently, an investigation for 1200 patients with acute renal failure show that 28.9% of them iare caused by taking nephrotoxic medicines. That is to say, they have to depend on dialysis for survival in their rest life just because of careless medicine intake.
Then we are curious that what medicine can damage kidney and how to avoid these injuries.
Kidney is the most important secretion organs, most of medicines can be discharged through urination. Through renal compression, the content of water-soluble medicine in urine can reach up to 100 times that in plasma. If this medicine are nephrotoxic, it can be imaged what damage they can incur to kidney.
1. Antibiotics.Stem Cell Therapy for CKD Stage 5 Patients
Above all, Aminoglycosides can arouse tubular necrosis. Their nephrotoxic strength can be ranged as Neomycin, Gentamycin, Kanamycin and Amikacin, tobramycin and streptomycin, their nephrotoxin are decreasing one by one. In clinical practices, gentamycin are the most commonnephrotoxic medicine. The longer medicine be taken, the more severe toxin can cause.
The second type is Penicillin and cephalosporin.Micro-Chinese Medicine Osmotherapy and Stem Cell Therapy
Penicillin can cause various allergic mesenchyma nephrotitis, and methicilin and ampicillin are very common in clinical practices. Large dosage of Penicillin G, etc can impinge tubular on reabsorbing potassium, which can cause hypokalemia. The first generation of cephalosporin can cause nephrotoxic impairment, especially for cephaloridine. Whereas, cefalexin and Cefradine has unobvious nephrotoxic damage on kidney. Cefazolin, the third generation cephalosporin like cefotaxime, cefoperazone also has a slight nephrotoxic injury to kidney. Renal impairment caused by penicillin and Cephems antibiotics are usually irreversible. Most patients can recover if they stop taking these medicines.Stem Cell Therapy Treats Kidney Disease
The third one is tetracycline. This medicine can not cause nephrotoxic damage to kidney, it can increase the concentration of blood urea nitrogen which can aggravate the illness condition of patients with kidney disease. Otherwise, the metabolic product of overdue or deteriorated tetracycline can cause a direct impairment to kidney. Demeclocycline can trigger renal insipidus and acute renal failufe. Doxycycline can not arouse azotemia generally.
The forth one is anphotericin. This medicine can result in azotemia, tubular necrosis. The strength of nephrotoxicity is associated with dosage administrated. Old people and people who have insufficient blood volume are more likely to encounter renal impairment.Shijiazhuang Kidney Disease Hospital and Huaxia Nephropathy Research Institute
The sixth one is rifampicin. People who are allergic to rifampicin are more likely to suffer from acute Mesenchyme Nephritis which usually happens when people take medicines discontinuously. Some patients are even adjoint with liver injury, plate decrease and hemolysis in blood vessels.
The sixth one is sulfanilamide. This medicine can cause obstructive nephropathy, allergic vasculitis, messenchyme nephritis and nephritic syndrome
Cold medication and analgesic-antipyretic
There are variety of cold medication in market. The prevalent types in clinicalpractices are mainly analgesic-antipyretic and anti-allergic medications. If taking two or more cold medication simultaneously, people are more likely to suffer from renal lesion induced by medicines. In clinical cases, analgesic-antipyretic can cause many kinds of renal lesion, the earlier symptoms include renal concentration function decline, frequent urination and enuresis nocturna. Some patients can not present any symptoms but present renal failure over time.
Hypotensor.Is There any Treatment Available for Kidney Problem and Is There a Natural Remedy for CKD
angiotensin converting enzyme inhibitor (ACEI) is a prevalent medicine in clinical practices due to its pleasant function on decreasing blood pressure. In addition, it can reduce proteinuria(Proteinuria and Kidney Disease). However, it is reported that the first generation of ACEI can induce acute reversible renal failure, acute messenchyme nephritis, renal failure aggravation and hyperkalemia etc. Though the newly-developed ACEI cause less side-effects obviously, it is advisable for Chronic Kidney Disease(CKD) patients whose Serum Creatinine has exceeded 265 umol/L not to take this kind of hypotensors, preventing renal function aggravating and hyperkalemia.
Hypoglycemics.Treatment Options for Stage 4 Chronic Kidney Disease (CKD)
Melbine DMBG can be digested without liver metabolism, they get secreted with original form through kidney. Under normal dosages, this medicine can not impair Dietetic patients with normal renal function. However, DMBG and lactic acid are more likely to accumulate in human body if renal function encounters problem and this can cause acid poisoning. Hence, it is advisable to monitor renal function regularly if patients take medicine for long. Patients need to stop taking DMBG once Serum Creatinine exceeds 133umol/L.Is Stage 4 CKD (Chronic Kidney Disease) Curable

Undoubtedly, there are still some medicines which are still obscure about their nephrotoxicity. But one point is clear that Chronic Kidney Disease(CKD) patients need to pay more attention to this when you need to take some medicine to treat other diseases, like controlling blood pressure, treating cold or infection etc. Because the majority of metabolic product of these medications are discharged by kidney, once renal function encounters dysfunction, kidneys’ filtration and concentration can not perform well. In this case, these nephrotoxic medicines will accumulate in CKD patients’ body and induce further damages to those remaining nephrons. At last, patients with Chronic Kidney Disease progress rapidly into acute renal failure and Uremia.

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