Ⅰ. Reducing of Erythrogenin
Our kidneys can produce erythrogenin which is a hormone-like substance. Erythrogenin can promote the generation of red blood cells. Due to renal damage, renal erythropoietin reduces, leading to the decrease of red blood cells in the blood. Reducing of erythrogenin is the major cause of renal anemia.
Ⅱ.Accumulation of Hazardous Substances
In the end stage of renal failure, a mass of hazardous substances accumulate in the body. On one hand，these hazardous substances restrain hematopoietic function of marrow, which means that new blood can not be produced，on the other hand they can restrain the activity of the erythropoietin, resulting in the destruction of red blood cell membrane, which will shorten the life span of red blood cells. As a result of these two points, red blood cells decrease, so as to cause renal anemia.Kidney Failure With Severe Anemia
Ⅲ. Malnutrition
The limited intake of protein for patients with Chronic Kidney Disease, coupled with increased leakage of protein, decreases the concentration of plasma protein. Protein is the material of producing blood. Therefore, when protein reduces, the blood in our body will reduce, so as to give rise to anemia.Anemia and Kidney Disease and Gopal Chandra Basak, Anemia, Hypertension, Diabetic Nephropathy
Ⅳ. Bleeding.Stage 5 Chronic Renal Failure and Anemia Diagnosis
Patient with Chronic Kidney Disease, especially those who are in the end stage of chronic renal insufficiency, often have tendency of bleeding. For example, they usually have epistaxis, bleeding gums and malabsorption of our body to ferrum. These will cause the insufficiency of ferrum in the body, causing renal anemia.
Beyond that，shortage of necessary substances will also cause anemia. Owing to long time renal insufficiency, patients usually have symptoms of anorexia and diarrhea. This will give rise to shortage of folic acid, vitaminB12 and other necessary substances of our body causing anemia.
