Symptoms in The End Stage of Chronic Kidney Disease
Ⅰ. Patients with Uremia will have symptom of anemia definitely. Anemia is usually caused by following reasons.
1. Decrease of erythropoietin. When kidneys get damaged severely, EPO could not get enough secretion, which promotes the production of red blood cells.
2. Retention of metabolic products (such as methylguanidine, guanidinosuccinic acid and so on) restrains the maturity of the red blood cells and damages red cell membrane, which shortens lifespan of red blood cells. Besides, toxic substances(such as erythropoietin inhibitory factor) in blood can inhibit the activity of erythropoietin.
3. Patients with Uremia have symptoms of anorexia, diarrhea and bleeding is easy to occur on them, which will lead to deficiency of iron, folic acid and protein. Loss of protein(especially transferrin) in urine can also cause anemia. Except anemia, patients with Uremia are easy to bleed, such as sub dermal ecchymosis, epistaxis, gum bleed, melena and so on.Stem Cell Therapy Treats Kidney Disease or Kidney Failure and Acupuncture for Kidney Disease in Huaxia Nephropathy Research Institute
Ⅱ. Symptoms of nervous and mental : listlessness, fatigue, feeling dizzy, headache, deterioration of the memory, insomnia, pins and needles, itchy skin. Even patients can not stand pain and itch of lower limb and they need move frequently. In the end stage of chronic kidney disease, the following symptoms can occur: sleepness, fidget, delirium, muscle cramp and coma. Symptoms of nervous and mental may result from combined action of metabolites retention, disturbance of water and electrolyte balance, metabolic acidosis and high blood pressure to nervous .Suggestion for ESRD Patients to Improve Kidney Function
Ⅲ. Metabolic disturbance. Patients with Uremia all have metabolic disturbance of different degree. Due to malnutrition, decrease of protein synthesis, loss of protein in urine, many patients with Uremia will have obvious hypoproteinemia and become very thin. The essential amino acids level in blood falls and level of most of non-essential amino acids rises. In addition, hyperlipidaemia often occurs on patients with End Stage Renal Disease(ESRD). Does It Mean You Are Dying If You Have Stage 5 Kidney Failure
These are the symptoms in the end stage of renal failure. It is quite important to realize these symptoms and take proper treatment to block its further aggravation. The earlier you take action, the more chance you can get improved. And if you any problems you can consult our online experts or send email to us. We would try our best to help you get rid of sufferings.